Traveling to high altitude destinations like Cusco, La Paz, or Lhasa requires preparation. Altitude sickness can hit anyone — even fit, experienced travellers — so having the right gear before you go can make the difference between a miserable trip and a great one. Here's what to pack.
Your first line of defence is prevention. Start before you even land. If you're heading somewhere above 2,500m, speak to your doctor about Acetazolamide (Diamox), a prescription medication that speeds up acclimatisation. For over-the-counter options, these products have strong reviews from high-altitude travellers:

72-hour continuous protection. These patches are the most convenient way to manage symptoms while on long trails.

The complete toolkit. Includes patches, tablets, and roll-on. Best for those travellers unsure of how their body will react.
Even with preparation, symptoms can still strike. Headaches, nausea, and breathlessness can come on quickly at altitude — these are the items to reach for when they do.

95% pure oxygen for immediate relief of shortness of breath. Essential for those landing directly in high-altitude cities.
Note: canned oxygen cannot be brought on a plane, but it is widely sold in pharmacies and tourist shops in most high altitude cities — you should have no trouble finding it when you arrive.

Fast-acting roller for on-the-spot relief from headaches and nausea. Compact enough to carry in any pocket or bag.

Drug-free herbal inhaler for instant nausea relief. Fits in any pocket — ideal for the moment symptoms hit mid-hike.
Staying hydrated is one of the most effective things you can do at altitude. Aim for 3–4 litres of water per day, and consider adding an acclimatisation drink mix to support your body as it adjusts.

Caffeine-free hydration tablets with ginger to prevent nausea and boost oxygen intake. Just drop one in water before ascending.

Natural drink mix with Rhodiola and Ginkgo to support acclimatization, hydration, and energy at altitude. Great for pre-hike prep.